fbpx Cancer Research | Istituto di Candiolo - FPO - IRCCS
The MET Oncogene in Glioblastoma Stem Cells: Implications as a Diagnostic Marker and a Therapeutic Target
Cancer Res. 2013 May 21. [Epub ahead of print] Boccaccio C, Comoglio PM.
The MET oncogene, a crucial regulator of the genetic program known as "invasive growth" or "epithelial-mesenchymal transition," has recently emerged as a functional marker of glioblastoma stem cells. Here, we review findings that associate MET expression and activity with a specific, genetically defined glioblastoma stem cell subtype, and data showing how MET sustains the stem cell phenotype in glioblastoma and other tumors. Finally, we discuss issues related to identification of tumorigenic clones driven by MET in the context of genetically heterogeneous tumors and strategies aimed at eradicating cancer stem cells
Publication Date: 
Giovedì, Maggio 23, 2013


Raggiungi l'Istituto di Candiolo


  •  Indirizzo per navigatori: Strada Provinciale 142 di Piobesi incrocio Strada Statale 23 del Sestriere  -  Coordinate: 44°58'01.6"N 7°34'00.0"E